Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1	Vms1 , ZNF744	Homo sapiens	14	protein-coding			617541

Summary

Predicted to enable metal ion binding activity. Involved in cellular response to hydrogen peroxide. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004521	enables RNA endonuclease activity	IDA

Component (2)

Go ID	Value	Evidence
0005737	located_in cytoplasm	IDA
0016020	located_in membrane	HDA

Process (4)

Go ID	Value	Evidence
0036503	involved_in ERAD pathway	IBA
0070301	involved_in cellular response to hydrogen peroxide	IMP
0006515	involved_in protein quality control for misfolded or incompletely synthesized proteins	IDA
0072344	involved_in rescue of stalled ribosome	IDA

Gene Loss events - ANKZF1 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_GIGPK1	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_J6AQKB	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_MVTB3J	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_OQ9FG4	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671